The Zhang lab tackles the problems related to how virus interacts with cell, and transforms normal cells into cancerous ones. Mayo Clinic Summer Undergraduate Research in Nephrology and Urology Director. We hypothesize that robust activation of IRF3 induces a high level of IL-6 expression that contributes to viral control but also causes damage to the hippocampus. The Department of Neuroscience & Cell Biology at Rutgers-RWJMS. First preference is given to students who have received the L.S. Lindsley F. Kimball Research Institute/New York Blood Center Paid Summer Internship. ISB Summer Undergraduate Research Experiences Program. Infection by the chlorella viruses resembles bacterial infection by tailed bacteriophages in many respects. A parallel project is to study the transmission of a human herpesvirus, known as the Kaposi’s sarcoma virus in both Zambia and Tanzania, which is linked to KS in AIDS patients. Each year, NCV invites applications for our Undergraduate Summer Research Experience in Virology (USREV) program from students enrolled at institutions in Nebraska as well as other states, who are motivated to explore the exciting opportunities for careers as scientists in biomedical research, while working with our experienced research faculty along side current graduate students and postdoctoral research associates in their labs. Zhang lab has been testing a novel approach to specifically block the viral transformation events that lead to the development of human cancers. Each year, NCV invites applications for our Undergraduate Summer Research Experience in Virology (USREV) program from students enrolled at institutions in Nebraska as well as other states, who are motivated to explore the exciting opportunities for careers as … They study neuroAIDS and whether the brain can serve as an HIV reservoir, how HIV is transmitted from mothers to their infants, and how the virus evolves into new strains to develop drug resistance in infected individuals in Zambia. The current major projects in our laboratory are described below. Research Projects Staff and students in the Virology Division of the Pathology Department pursue a wide range of research interests on many different viruses and their interactions with hosts. While significant progress has been made toward identifying viral and bacterial components which are found to be “foreign” and activate the immune system, much remains to be learned. This research is leading to a comprehensive understanding of fundamental biological processes, development of novel therapeutics to combat infectious diseases, and the engineering of new resources that are of use to humanity. See you all next year! Other research opportunities at the University of Nebraska. In the first and second years, students also participat… Always check with the individual program's website for details. The Quantitative Biology Undergraduate Summer Research Program offers summer research fellowships to undergraduates. Undergraduate study. Second, vaccine platform design explores the use of alternative viral vectors as vaccines, as well as the development of safer more effective viral vaccine platforms. The Department of Biology at Tufts University offers a NSF funded summer research program entitled "Integrative approaches to studying recognition systems in cells, organisms, and populations" in which 12 undergraduate students will work closely on a collaborative, interdisciplinary project. During your internship, you will put your knowledge into practice while taking part in exciting, cutting-edge research. In spite of the presence of self-reactive T cells in the naïve peripheral repertoires, autoimmune responses do not ensue spontaneously. Research Interests: The Wood laboratory focuses on HIV/AIDS and AIDS associated cancers in Africa. To this end, we focus our investigations on the identification of microbial products that can potentially induce autoimmunity in the heart and immunologically privileged sites such as the central nervous system and eyes through antigenic mimicry. Individuals who want to work in virology research are typically required to complete an additional 3-5 years of postdoctoral research training, often called a … Tropism, immunopathogenesis, and vaccinology of porcine reproductive and respiratory syndrome virus (PRRSV) a major pathogen of swine. Contact us; Legal. EBV infection has been associated with the development of several human cancers. The innate immune response to viral infection depends on Interferon Response Factor-3 (IRF-3), which plays a key role in induction of Type I interferons (IFN-alpha/beta), IL-6, and IL-12. Funding for the Summer Research Program is provided by the National Science Foundation, the Department of Defense, the Nebraska Center for Virology, and the Vice Chancellor for Research. Anonymous 02/10/21(Wed)00:01:56 No. Research Interests: Qingsheng’s research focuses on better understanding the interaction of human immunodeficiency virus type-1 (HIV-1) with its host in the earliest infection to elucidate key steps and critical events in the mucosal transmission of HIV-1, to identify correlates of protection, and ultimately to develop an effective anti-viral topical microbicide and vaccine. We also have extensive contacts with virologists in the Department of Medicine and Department of Veterinary Medicine and research projects may be offered in these. Our main interest is to find what do virus have in common, as a first step toward broad spectrum antiviral or even vaccines. The graduate experience in the Microbiology and Molecular Genetics Program (MMG) begins with an introduction to the faculty, current students, and their research through a series of short talks, discussions, and a poster session. The successful applicant will gain skills in: General laboratory work, general microbiology theory, microbe culturing, flow-cytometry, proteomic and metabolomics sample collection, ocean nutrient data collection, and data … The chlorella viruses have genomes as large as 370 kb that contain as many as 400 protein encoding- and 16 tRNA encoding-genes. You will also learn about the problems associated with the production of vaccines. We anticipate that a small epitope might elicit potent neutralizing antibodies against the virus. . Cell and Molecular Biology - Cancer Biology - Cell Biology and Physiology - Developmental, Stem Cell, and Regenerative Biology - Gene Therapy and Vaccines - Genetics and Gene Regulation - Microbiology, Virology, and Parasitology. This program allows undergraduate students majoring in biology, engineering, mathematics, statistics, or physics to participate in hands-on laboratory or computational research that applies mathematical concepts and methodology to understanding … Columbia/Barnard students interested in the SURF Program can apply from January 4th until February 16th, 2021.. Our undergraduate summer research internships are a unique opportunity to learn whether the world of research is for you. Also, potential treatment of human cancers is also on their agenda. The students then choose the first of three research rotations which are designed to give the student exposure to various research areas and techniques before choosing a direction and laboratory for their thesis research. The Nebraska Center for Virology (NCV) faculty research challenging topics addressing problems of epidemic proportions facing mankind including AIDS and HIV replication and pathogenesis, herpesvirus latency and cancer, human papilloma virus and cancers, and chlorellavirus biology. A second topic of interest is the analysis of the packaging requirements for HPVs. Studies in my laboratory focus on molecular biology and immunopathogenesis of two different viral pathogens, the vesicular stomatitis virus (VSV), a non-segmented negative-strand RNA virus in the family Rhabdoviridae and order Mononagavirales, and the porcine reproductive and respiratory syndrome virus (PRRSV), a positive-strand RNA virus in the family Arteriviridae and order Nidovirales. More recently, Dr. Angeletti has begun cervical cancer screening studies in Tanzania, which is funded by the National Cancer Institute (NCI). Therefore our central hypothesis is that differences in host IRF-3 underlie persistent infections with certain viruses but also immune mediate damage during viral infections. Program Description. My current research explores the use of bioinformatics, phylogenetics, immunology and molecular biology to study the basic mechanisms of host-pathogen interactions and to create improved vaccines against microbial diseases. In addition, we are also working on small ruminant lentviruses (SRLV) and try to find the genetic resistant-forms against SRLV infection. Mechanistically, we are particularly interested in delineating the role of antigen-specific T cells in the autoimmune diseases of infectious origin. Our goals include designing novel vaccines and therapeutic strategies to block disease. Viral entry is a critical step for establishing infection, thus providing a powerful incentive to understand the intricate biochemical mechanisms of viral entry as a prerequisite for developing effective antiviral therapies. It has been suggested that the environmental antigens that bear similarities to self-antigens break self-tolerance by cross-reactivity. Summer Undergraduate Research in Biology (SURB): Interdependence Across Subdisciplines REU at Pepperdine University. … Summer research opportunities will be available in a variety of biological and biomedical sciences including (but not limited to): cellular and developmental biology, cell cycle regulation, stem cell biology, studies of blood cells, cancer biology, endocrinology, immunology, microbiology, molecular biology, genetics, neuroscience, receptor structure and function, transmembrane signaling mechanisms, and virology… You will normally work on a research project in either virology or immunology. Interested students entering their junior or senior year will be selected on the basis of the completed application. The Summer Undergraduate Research Programme (SURP) provides an opportunity for international undergraduate students to undertake research attachments for eight weeks. For information on how to apply, visit the SURP application site. Accessibility statement; Freedom of information; The Rockefeller University’s Summer Undergraduate Research Fellowship (SURF) program is designed to provide qualified, highly motivated college students majoring in the life or physical sciences, an opportunity to experience laboratory research. Over 70 research projects are offered, across eight different subject areas. For more information on the overall goals and structure of SURP please visit the SURP homepage. In these studies, Angeletti looks at the affect of HIV upon formation of HPV-related neoplasms. Mayo Clinic Graduate School of Biomedical Sciences offers a … Another approach involves epitope-based antigen design. These viruses are ubiquitous in fresh water from all over the world. Associate Professor, Nebraska Center for VirologySchool of Biological Sciences402-472-3986. and medical students (who do not hold a graduate degree) to become involved in projects relating to biomedical research. For further information contact the program-specific PMI faculty: Dr. Penelope A. MorelUniversity of Pittsburgh School of MedicineE1055 Biomedical Science Tower 200 Lothrop St.Pittsburgh, PA 15261, Dr. Kathy ShairUniversity of Pittsburgh School of MedicineUPMC Hillman Cancer Center, lab 1.85117 Centre AvenuePittsburgh, PA 15213, Immunology Seminar Series (Schedule and Recordings), Immunology Faculty Research in Progress Series, Immunology Student/Postdoc Research in Progress Series, University of PittsburghDepartment of ImmunologyE1040 Thomas E. Starzl Biomedical Science TowerPhone: 412-383-9737Fax: 412-383-8098, Cool PittsburghPitt HomeHealth Sciences HomeGraduate Program, Interested students entering their junior or senior year. UNL web framework and quality assurance provided by the, School of Veterinary Medicine and Biomedical Sciences, Department of Oral Biology, College of Dentistry, Apply to the University of Nebraska–Lincoln, Give to the University of Nebraska–Lincoln, 2021 Agricultural Sciences, Land Grant University, Current undergraduate with at least one semester of coursework remaining before obtaining a bachelor's degree, Full access to the Campus Recreation Center and campus library system, Professional development workshops (e.g., applying to graduate school, taking the GRE). This program gives preference to and encourages applications from students whose primary interest is exploring a career in biomedical research. (ii) Unlike other glycoprotein-containing viruses, chlorella viruses encode most, if not all, of the components required to glycosylate their proteins. Application Instructions Link to online application. Summer Program in Molecular Biosciences. American Heart Association 212-878-5912 Summer Fellowship Program 10 weeks Minimum GPA 3.0. Hernan is a virologist interested in the molecular mechanisms of viral RNA replication and in antiviral RNA silencing. Amgen Scholars Program 617-253-2620 Summer Research Program 10 weeks Sophomores, Juniors, Seniors. If so, check out Mayo Clinic Graduate School of Biomedical Sciences. You will then conduct exciting and challenging experiments to test hypotheses under the guidance and mentoring of our expert faculty. Cellular and molecular mechanisms of auto-immunity. SURF students are matched according to their stated field of interest with faculty, postdoctoral researchers or graduate students. In immunocompromised individuals, such as organ transplant recipients or AIDS patients, EBV almost certainly causes two fatal cancers: post-transplantation lymphoproliferative disorder (PTLD) and AIDS-associated central nerve system (CNS) lymphoma. In other strains of mice, TMEV is eliminated within a few weeks. Please indicate whether your major interest is in microbiology or immunology, and include any reasons or experiences that help to explain your interest. The topics of research include virus structural biology, genome replication, gene expression, translational mechanisms, assembly and egress, pathogenesis, immune evasion, comparative genomics, virus evolution and antiviral resistance. Initial research will focus on the interconnection between RNA replication and RNA silencing mechanisms in viruses using yeast and plants as model systems in combination with genomic and bioinformatics approaches. Role of IRF-3 in pathogenesis, as well as innate and adaptive immunity during Theiler’s Virus infection. Program in Microbiology and Immunology (PMI). Consequently, these proteins serve as models for mechanistic and structural studies. Development of influenza vaccines that promote cross protection and induce T cell memory responses to conserved antigens. Under the guidance of a selected PMI faculty member, the student will participate in the ongoing research efforts of the laboratory. Students will conduct research under the supervision of a CUHK faculty member. AMA >> Anonymous 02/10/21(Wed)00:01:56 No. Hernan comes to UNL from the Donald Danforth Plant Science Center, where he was a research scientist. 12688621 >>12688615 >top 5 engineering school Well, which one? The University of Nebraska Medical Center has research projects ranging from basic molecular biology to the study of human disease in clinical settings. The first topic involves the analysis of cis and trans-acting signals required for stable replication of HPVs. Another area of study is the role of HPV in ocular surface squamous neoplasm (OSSN) in the sub-Saharan African country of Zambia. Replication and pathogenic mechanisms of RNA viruses. We showed that failures within the innate immune system are causes of TMEV persistence but also protect the mice from immune mediated damage to host tissues. Research Interests: Dr. Angeletti’s research is focused on topics relating to sexually transmitted Human papillomaviruses (HPVs). The following items are required: 1) Curriculum Vitae/Resume. It is hypothesized that in some cases these persistent viral infections lead to diseases, such as Multiple Sclerosis (MS). The Microbiology Undergraduate Summer Research Award is open to undergraduate microbiology majors who are performing independent research on the Bloomington campus during the summer. One of the most fundamental questions in the field of immunology is how our immune system identifies an invading pathogen as “foreign” rather than “self”. Romero, Michael F. Ph.D. Summary. In some strains of mice, TMEV persistently infects macrophages of the immune system but is never eliminated within the lifetime of the individual mouse. Due to the significance of the subject for U.S. animal agriculture, we focus on a major viral agent that affects swine: Porcine Reproductive and Respiratory Syndrome Virus (PRRSV, an arterivirus, ssRNA+ genome). Academic Summer Undergraduate Research Experience (ASURE)/Leadership Alliance: Dartmouth College: Hanover: NH: 2/1/21 : Summer Undergraduate Mentorship Program: Albert Einstein College of Medicine Hispanic Center of Excellence: Bronx: NY: 3/2/20 : Amgen Scholars Science and Biotechnology Undergraduate Research Program: Columbia University/Barnard College, Massachusetts Institute of … About thirty years after the identification of HIV as the causative agent of AIDS, the AIDS epidemic remains a global health issue. The program is sponsored and administered by the Program in Microbiology and Immunology (PMI) at the University of Pittsburgh’s School of Medicine. Most healthy individuals have a propensity to develop autoimmune diseases, as evidenced by the presence of autoreactive T cells in their naïve periphery. (iii) Many chlorella virus-encoded proteins are either the smallest or among the smallest proteins of their class. We will investigate the interactions between gp120 and the coreceptor CCR5 or CXCR4, employing various molecular and cellular approaches to dissect these associations in more detail. Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS (Acquired Immune Deficiency Syndrome). We also use a T cell receptor (TCR) transgenic (Tg) mouse model in which all of the CD4 T cells recognize a piece of the influenza virus and various "knock-out" mouse strains lacking important immune response genes to determine which type of CD4 T cells provide protection to lethal influenza infections which will further our understanding of CD4 T cell biology and provide a framework for developing oval vaccine formulations to combat highly pathogenic and emerging influenza virus strains. The IMV has a mission to conduct research and training in the area of virology, primarily at the molecular level, and to serve as the coordinating focus on the UW-Madison campus for research and training in virology. The Summer Undergraduate Research Program celebrates over four decades of continued success. Each year, outstanding college sophomores and juniors are chosen from a large pool of applicants. The focus is to determine how frequent is the infection by this virus, its route of transmission, the mechanism that this viruses causes cancer and how HIV acts as a co-factor, especially in AIDS patients. Collectively, results obtained from these studies will be valuable for the optimal design safe and effective vaccines against divergent viral strains circulating in the field. Research in the Van Etten laboratory focuses on the isolation and characterization of large icosahedral, dsDNA-containing, plaque-forming viruses that infect certain unicellular, eukaryotic chlorella-like green algae. As you are being trained in biomedical research, you will have the opportunity to explore cutting edge techniques and gain knowledge of the latest instrumentation by utilizing the equipment in our labs and the core facilities that provide support to our entire NCV faculty. The Department of Biological Sciences at Columbia University offers Summer Undergraduate Research Fellowships to a select group of motivated undergraduate students who will benefit from the opportunity for hands-on biology related laboratory research. HIV-1 is an enveloped virus, requiring for cell entry a membrane fusion process mediated by the interactions of viral envelope glycoproteins (gp120 and gp41), a primary receptor CD4, and a chemokine coreceptor (CCR5 or CXCR4). My laboratory studies two important viruses of swine: porcine reproductive and respiratory syndrome virus (PRRSV) and influenza A virus of swine (IAV-S). There will also be program-specific events tailored to inform SURP students in PMI of how to build a research career in microbiology or immunology. Epitope information gleaned from studies of known neutralizing antibodies such as VRC01, b12 or 2G12 should facilitate fragment structure-based design. We showed that IL-6 induces activation of STAT1 and ERK and thus is a key antiviral cytokine during this response to TMEV. In addition, we are also working on small ruminant lentiviruses (SRLV) and try to find the genetic resistant-forms against SRLV infection. Ecology & Environmental Sciences . HIV and Kaposi’s sarcoma associated human herpesvirus transmission, evolution, and disease pathogenesis. In the ten-week program, all SURP students will gain experience in basic laboratory skills, participate in lab meetings and connect weekly with other SURP students in the form of a journal club, seminar series, lunch meeting with selected speakers and social activities. >> Anonymous 02/10/21(Wed)00:02:26 No. 12688626. Characterization of large dsDNA viruses that infect certain chlorella-like green algae. My research centers on pathogenesis of and immune response to viral infections. The summer intern will work closely with a PhD student to measure the growth rate of the novel bacterium grown with glycolate and other organic carbon sources found in nature. When this decision is made correctly growth of the virus or bacteria can kept at a minimum. It offers talented undergraduates a unique opportunity to conduct key research and gain valuable skills while exploring career opportunities in the sciences. We use chemical virology to identify commonalities among unrelated viruses. Once you have experienced the Summer Undergraduate Research Fellowship, you may be interested in obtaining your graduate degree at Mayo Clinic. Learn more about academic and financial benefits. May 30, 2017 – August 3, 2017. HPV replication, encapsidation, and pathogeneses. Herpesvirus-host interactions in innate immunity and cancer formation. Envelope-Based AIDS Vaccine Development. Today, Drs. Funded by the National Science Foundation, the Research Experience for Undergraduates program is a summer research experience in animal behavior. Immune response against porcine respiratory and reproductive syndrome virus (PRRSV), and development of vaccines. Thanks to all of the speakers, organizers and attendees who made it such a success. Recipients are required to write a publishable manuscript that reports the results of their research. Rutgers School of Graduate Studies. was held virtually on Thursday, October 8, 2020. The approach involves stabilizing a CD4-bound conformation of gp120, in which CD4 as well as the co-receptor (CCR5 or CXCR4) binding sites are exposed. Plant-virus interactions, anti-viral RNA silencing, RNA virus replication and their interconnections. The HIV-1 envelope has evolved such an immunosuppressive state that does not provoke adequate immunogenicity to trigger the production of neutralizing antibodies. Summer Undergraduate Internship Program (SUIP) ... Research areas available to SUIP students include: Biochemistry and Molecular Biophysics. Follow the application steps to submit the following materials. You will gain experience by learning how to conduct research and from many additional rewarding, enjoyable opportunities for our students including social and recreational activities, and cultural events, as well as self-help seminars that will prepare you in all aspects of graduate school life and beyond including resume writing, graduate school applications, test taking, grant writing and more. REU is open to IU and non-IU undergraduate students. NIH/NIMH "Summer Undergraduate Research Program in Molecular and Developmental Neurobiology" (Award #R25MN09572). Our research interests are focused on HIV/AIDS, with the ultimate goal of developing an effective vaccine or a long-term preventive strategy to counter this devastating pandemic. Got accepted to summer undergraduate research fellowship at a top 5 engineering school with no prior research experience. The University of Glasgow is a registered Scottish charity: Registration Number SC004401. This gp120 antigenic conformation should induce a much stronger immune response, and consequently, elicit more potent neutralizing antibodies. Undergraduate study menu. However, failure to recognize an invader extends the amount of damage it may produce or, if self is incorrectly regarded as foreign, then autoimmune disease occurs.
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